In Vitro Assays

CIDP Preclinical offers a wide range of in vitro assays for safety and toxicity, efficacy, and antiviral assessment. Our tests have been developed and validated according to international guidelines (ECVAM, OECD and ISO). The assays are performed in strict compliance with Good Laboratory Practice (GLP). We also design and advise on tailored assays to meet your specific requirements for your product development and validation process.

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Safety and Toxicity Services

  • Skin irritation & corrosion
  • Eye irritation (Bovine Corneal Opacity and Permeability Test (BCOP) and Fluorescein leakage Test)
  • Skin sensitization (human Cell Line Activation Test (h-CLAT))
  • In vitro  mammalian cell micronucleus test (MNvit))
  • Phototoxicity
  • Cytotoxicity (Cytotoxicity test (ISO 10993-5:2009), Propidium iodide (PI) DNA staining, Agar overlay assay, NEUTRAL RED UPTAKE (NRU) cytotoxicity test)
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Efficacy Services

  • Antioxidant/anti free radical activity (Cellular antioxidant activity, different radical initiator can be used including H2O2, AAPH, UV, Blue light, Pollution)
  • Collagen/elastin synthesis (anti-collagenase or elastase assays, immunostaining, scanning electron microscopy images)
  • Anti-ageing activity (Collagenase (MMP-1) Inhibition assay)
  • Anti-inflammatory (Pro-inflammatory cytokines (such as IL-6, IL-1α Inhibition assay)
  • Whitening/tanning activity (Cellular Tyrosinase Inhibitory Activity Assay, Melanin content assay)
  • Healing activity
  • Cell proliferation